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Chemistry Seminar: Structure and Dynamics of Microtubule-Associated and HIV-1 Protein Assemblies
Start Date: 10/29/2015Start Time: 4:30 PM
End Date: 10/29/2015End Time: 5:30 PM

Event Description
Tatyana Polenova, PhD, Department of Chemistry, University of Delaware

 

“Structure and Dynamics of Microtubule-Associated and HIV-1 Protein Assemblies by Magic Angle Spinning NMR Spectroscopy”

Microtubules (MTs) and their associated proteins (MAPs) play important roles in vesicle and organelle transport, cell motility and cell division. Dynactin multisubunit assembly is the activator of the cytoplasmic microtubule-based dynein retrograde motor complex. CAP-Gly microtubule binding domain of dynactin's p150Glued subunit is critical for the regulation of dynein's motility. Mutations in the CAP-Gly domain are associated with neurological disorders, but the mechanism by which the CAP-Gly domain recognizes microtubules remains largely unknown, particularly at the atomic level. I will present the 3D structures of CAP-Gly free and assembled on microtubules, determined by magic angle spinning (MAS) NMR. I will discuss the insights gained into structural and dynamic basis of CAP-Gly’s biological function and interaction with its binding partners and microtubules. HIV-1 capsid proteins (CA) assemble into cone-like structures and enclose the viral RNA genome together with a small complement of proteins during viral maturation. CA exhibits structural polymorphism and can assemble into various morphologies, such as cones, tubes, and spheres. I will present our recent investigations into the structure and dynamics of CA assemblies and their complexes with a host cell protein cyclophilin A. To study the above assemblies, we have focused our efforts on establishing NMR methodologies that overcome sensitivity and resolution challenges. An overview of these methods will be presented.
Contact Information:
Name: Prof. Frank Ji
Phone: 215.895.2562
Email: hj56@drexel.edu
Location:
Disque Hall, Room 109, 32 South 32nd Street, Philadelphia, PA 19104
Audience:
  • Undergraduate Students
  • Graduate Students
  • Faculty
  • Staff
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  • Free Food
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