| Start Date: | 10/11/2016 | Start Time: | 10:00 AM |
| End Date: | 10/11/2016 | End Time: | 12:00 PM |
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Event Description
BIOMED PhD Research Proposal
Title:
Generation, Computational Biofluid Mechanics, and Visualization of Complex Blood Flow Dynamics
Speaker:
Pablo Huang, Phd Candidate, School of Biomedical Engineering, Science and Health Systems
Advisors:
J. Yasha Kresh, Phd, Professor of Cardiothoracic Surgery, Medicine, and Biomedical Engineering
Ken Barbee, PhD, Professor and Interim Director, School of Biomedical Engineering, Science and Health Systems
Abstract:
Cardiovascular disease is the leading cause of death in the world. Hemodynamics plays a significant role in the development of atherogenesis, thrombogenesis, and other forms of cardiac disease. Geometry and tortuosity of vessels can disturb blood flow and create recirculation regions and areas of turbulence, activating mechanotransductive pathways in endothelial cells giving rise to vascular remodeling. With the advent of improved imaging technologies and techniques, flow in the cardiovascular system has been observed to contain variable spiral flow content, which has been speculated to have beneficial biological effects. A major promoter of complex blood flow is the heart itself. With each contracting beat, the heart’s helical fiber architecture imparts a twisting motion (like wringing a wet towel) and in the process generates spiral blood flow.
The proposed study aims to identify and characterize the attributes of blood flow patterns in realistic vascular models to help design and optimize spiral flow-inducers. Using computational fluid dynamic simulations, the mechanism by which spirality is preserved/regenerated, especially under pulsatile conditions will be studied. The process by which spiral flow helps order/reorganize fluid flow and thereby delay the transition point into turbulence (chaotic) regime will be investigated in great detail. The helical form dissipation/demodulation of spiral flow, as it is affected by prosthetic (bi- or tri-) leaflet valves, will also be studied.
Importantly, this work will serve as a foundation/framework for enabling the exploration of endothelial vascular wall response to spiral flow mediated mechanical forces. Spiral flow may create wall shear stress conditions beneficial for the prevention of vascular disease states. The expected impact is a wider recognition that spiral flow is pervasive and serves a physiologically critical vascular function. Mimicking and generating the spiral structural forms will help inform cardiovascular engineering designs (e. g. prosthetic valves, circulatory assist devices, cannulas, endovascular stents) that may prove to be paradigm changing. |
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Location:
Bossone Research Center, Room 709, located at 32nd and Market Streets. |
Audience:
Undergraduate StudentsGraduate StudentsFacultyStaff |
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