| Start Date: | 11/15/2013 | Start Time: | 4:00 PM |
| End Date: | 11/15/2013 | End Time: | 5:30 PM |
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Event Description
Wendy S. Vanden Berg-Foels, PhD, research assistant professor at Clemson-Medical University of South Carolina (MUSC), Bioengineering Program and Department of Craniofacial Biology, will discuss how adult articular cartilage mounts an ineffective healing response to injury resulting in joint degeneration and patient disability. Hyaline cartilage regeneration has been subject to extensive research; however, durable, long term repair is typically not achieved in the clinic. Little research has focused on regenerating the articular fibrocartilage of the mandibular condyle. This failure to deliver clinically translatable regeneration therapies has motivated a paradigm shift from empirical approaches to rational biomimetic designs based on developmental biology and wound healing concepts. Successful healing in adults, e.g., bone healing, recapitulates tissue morphogenesis and is orchestrated by a cascade of growth factors that direct endogenous mesenchymal stem cell (MSC) activities. Dr. Vanden Berg-Foels' guiding hypotheis is that robust in situ cartilage regeneration will be achieved by delivering an optimized growth factor cascade to orchestrate chemotaxis, proliferation, and chondrogenic differentiation by endogenous, synovium-derived MSC. She will present two focal points of her ongoing research: 1) recruitment of chondrogensis-capable MSC from the heterogeneous cell population in the synovial membrane and 2) evaluation of the cartilage collagen network structure by helium ion microscopy. For more info, please visit www.biomed.drexel.edu |
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Location:
Bossone Research Enterprise Center, Mitchell Auditorium (Bossone is located at the corner of 32nd and Market Streets). |
Audience:
AlumniCurrent StudentsFacultyProspective StudentsPublicStaff |
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