| Start Date: | 12/6/2013 | Start Time: | 4:00 PM |
| End Date: | 12/6/2013 | End Time: | 5:30 PM |
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Event Description
Dr. Delphine Dean, associate professor of bioengineering at Clemson University, will discuss several projects from her team's lab in which the nanomechanical properties and interactions of a variety of biological tissues are characterized. Specifically, she will discuss several results where they characterized directly individual cardiovascular cell mechanical properties as a function of microenvironment. Dr. Dean and her team used atomic force microscopy (AFM) in conjunction with confocal microscopy to directly measure cell mechanical properties and interactions. In addition, they have developed models of the single cells and their internal structures from the confocal imaging data so that they may have tunable levels of geometric complexity. These are then compared to our experimental measures of cell mechanical responses. For instance, they measured the effect of matrix composition and structure on cardiac cell mechanical properties in vitro. The extracellular matrix can modulate cell mechanical properties and these microenvironmental cues can lead to changes in cell phenotype and function. By creating engineered microenvironments using lithographic and nanoparticle techniques, Dr. Dean and her team can design experiments that will determine the dependence of cell mechanical function on environmental factors. The eventual goal is to build better models of the cardiac and vascular cell mechanical environment. For more info, please visit: www.biomed.drexel.edu |
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Location:
Bossone Research Enterprise Center, Mitchell Auditorium (Bossone is located at the corner of 32nd and Market Streets). |
Audience:
AlumniCurrent StudentsFacultyProspective StudentsPublicStaff |
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