Drexel University - Comprehensive, integrated academics enhanced by co-operative education, technology, and research opportunities. | Drexel University
Drexel University
Quick Links
Search events. View events.

All Categories

Click for help in using calendar displays. Print the contents of the current screen.
Display Format: 
Event Details
Notify me if this event changes.Add this event to my personal calendar.
Go Back
Novel Therapeutic Intervention for Myocardial Infarction in Large Animal Model
Start Date: 12/15/2017Start Time: 12:00 PM
End Date: 12/15/2017End Time: 2:00 PM

Event Description
BIOMED Master's Thesis Defense

Title:
Novel Therapeutic Intervention for Myocardial Infarction in Large Animal Model

Speaker:
Maria Mercedes, MS Candidate, School of Biomedical Engineering, Science and Health Systems, Drexel University

Advisors:
John Gearhart, PhD, Professor, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania

Fred Allen, PhD, Associate Teaching Professor, School of Biomedical Engineering, Science and Health Systems, Drexel University

Adrian Shieh, PhD, Associate Teaching Professor, School of Biomedical Engineering, Science and Health Systems, Drexel University

Abstract:
Heart failure (HF) represents an enormous clinical problem that imposes a significant burden to both
society and survivors. During a myocardial infarction, cardiomyocytes are damaged due to a lack of oxygen to the left ventricle and as a result these cells die. The dead cells are then replaced by fibrotic scar tissue that inhibits the heart from properly pumping blood to the rest of the heart.

The current treatments of HF do not reverse the damage that the left ventricle experiences, and as a result, many people experience recurrent heart failure and sometimes cardiac arrest. The field of reprogramming investigates the process of direct reprogramming of endogenous cardiac fibroblasts to cardiomyocytes as a novel approach to help the heart pump blood properly after a myocardial infarction.

In this project, we used a biodegradable hyaluronic acid (HA) hydrogel to encapsulate Adeno-associated virus (AAV) type 9 that was engineered to deliver a green fluorescent protein (GFP) reporter gene to a pig's heart post-myocardial. Our method represents a unique approach to transfect cardiomyocyte cells in vivo post-myocardial infarction in the pig. This study also demonstrates a cardiac functional improvement with the injection of hydrogel gel, AAV9, and selected transcription factors in the compromised area of the left ventricle.
Contact Information:
Name: Ken Barbee
Phone: 215-895-1335
Email: barbee@drexel.edu
Maria Mercedes
Location:
Bossone Research Center, Room 709, located at 32nd and Market Streets.
Audience:
  • Undergraduate Students
  • Graduate Students
  • Faculty
  • Staff
    		•

    Display Month:
    Advanced Search (New Search)
    Date Range:
    Time Range:
    Category(s):
    Audience: 

    Special Features: 

    Keyword(s):
    Submit
    Select item(s) to Search



    Select item(s) to Search
    Select item(s) to Search
    Select item(s) to Search