Conceptual and formal frameworks will be presented that allows us to understand how forces between charged macromolecular surfaces are influenced by the presence of quenched disordered charges on the boundaries. I will consider examples of monopolar and/or dipolar surface charge disorder in the case of confined Coulomb fluids and argue, that the presence of disorder can give rise to anomalously long-ranged normal and lateral interaction forces as well as torques. These disorder-generated interactions persist even for overall charge-neutral surfaces and can complicate the disentanglement of other long-range interactions, e.g. the Casimir interaction, from the observed forces. Furthermore, I will argue that in the case of strongly coupled Coulomb fluids, composed of multivalent and monovalent salt mixture with quenched disordered surface charges one can observe a peculiar type of antifragility where more imposed disorder actually diminishes the thermal disorder in the system, allowing the system to thrive on disorder.