| Start Date: | 4/5/2013 | Start Time: | 4:00 PM |
| End Date: | 4/5/2013 | End Time: | 5:30 PM |
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Event Description
Dr. Hao Cheng, assistant professor in the Department of Materials Science & Engineering, Drexel University, will discuss the fact that many life-threatening diseases involve inflammation, such as cancer and cardiovascular disease, and how stem cell membrane engineering is an emerging and promising modality in cell-based therapies. It utilizes intrinsic functions of cells to deliver therapeutics to inflamed tissues or enhances stem cell homing to sites of inflammation for tissue regeneration. We have developed chemical strategies to engineer stem cell membranes with biomaterials. In one application, nanoparticles were anchored on membranes of human bone marrow derived mesenchymal stem cells (hMSCs) that have tumoritropic migratory properties. This study is to explore new approaches to actively deliver nanoparticles for cancer therapy, as an alternative to the passive delivery methods. In another application, synthetic peptides were conjugated on cell membranes to engineer cell-selectin interactions and the engineered rolling process was Ca2+ independent, different from the Ca2+ dependent physiological process. This further illustrated the ability of this approach to control cell-microenvironment interactions. We used a mouse myocardial infarction model to demonstrate that membrane engineering can improve stem cell homing to inflammatory tissues, infarcted hearts after systematic administration. |
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Location:
The Papadakis Integrated Sciences Building, located on the northeast corner of 33rd and Chestnut Streets. |
Audience:
AlumniCurrent StudentsFacultyProspective StudentsPublicStaff |
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