Event Description
Sridhar Kannurpatti, PhD, assistant professor of radiology at RUTGERS-New Jersey Medical School, will discuss how methods to minimize vascular-related variability in fMRI-BOLD (blood-oxygen-level dependent) responses are important for obtaining veridical estimates of brain activity-induced hemodynamic response in pathologies such as stroke, traumatic brain injury and aging.
This can be accomplished by minimizing subject-to-subject variations in often inhomogeneous real-world patient populations. Using multiple modalities, Dr. Kannurpatti’s research integrates complementary methods, such as extracellular electrophysiology and optical imaging with fMRI to obtain a mechanistic framework of neuronal activity-related cerebral blood flow and neurovascular coupling in normal and pathological brain states.
A current application of the multimodal approach is directed towards pharmacologically facilitating mitochondrial function to assess its physiological impact on the brain's neural and hemodynamic activity in an animal model of mild traumatic brain injury. |
