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MicroCT-based Bone Dynamic Imaging and Biomechanical Modeling
Start Date: 5/1/2015Start Time: 4:00 PM
End Date: 5/1/2015End Time: 5:30 PM

Event Description
X. Sherry Liu, PhD, assistant professor in the McKay Orthopaedic Research Lab at the University of Pennsylvania, will discuss how her lab's research focuses on biological processes in bone and how they influence bone material, microstructural, and biomechanical properties with aging, disease, and therapies. One ongoing study focuses on osteoporosis treatment strategy by combining anabolic agents (e.g., intermittent parathyroid hormone PTH) and anti-catabolic agents (e.g., alendronate). By in vivo micro-computed tomography (uCT) and advanced in vivo dynamic imaging techniques we demonstrated an additive effect of combined therapy. Furthermore, we identified that this additive effect is achieved by enhancing trabecular bone connectivity and improving trabecular structure from rod-like to plate-like.

The second study investigates the influence of female reproduction on skeleton in a rat model. We found that pregnancy and lactation induce significant reduction in trabecular bone. After weaning the trabecular bone is partially recovered through trabecula thickening. However, the trabecular bone volume is still significantly lower than virgin controls. On the other hand, reproduction also induces cortical structure deficit; however, cortical bone material properties are significantly increased after reproduction, preserving the bone's mechanical function. Additionally we found that male rats has inferior trabecular bone structure than virgin female rats. The post-weaning trabecular phenotype is more similar to male rats than virgin females, suggesting that the female skeleton may initially contain more trabecular bone than needed to compensate for reproductive bone loss. For more info, please visit www.biomed.drexel.edu.
Contact Information:
Name: Ken Barbee
Phone: 215-895-1335
Email: barbee@drexel.edu
Biomed DEC.jpg
Location:
Papadakis Integrated Sciences Building (PISB), Room 120, located at the corner of 33rd and Chestnut Streets.
Audience:
  • Undergraduate Students
  • Graduate Students
  • Faculty
  • Staff
    		•

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