| Start Date: | 5/15/2015 | Start Time: | 4:00 PM |
| End Date: | 5/15/2015 | End Time: | 5:30 PM |
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Event Description
Eve Donnelly, PhD, assistant professor in the department of materials science and engineering at Cornell University, will discuss how bone tissue plays a critical structural role in the skeleton, yet the underlying microstructure-mechanical property relationships are incompletely understood, in part due to the complex hierarchical structure of the tissue. We examine biopsies from human patients to understand disease- and treatment-induced changes in bone composition and their relationship to osteoporotic fracture incidence and bone tissue from animal models to elucidate fundamental structure-property relationships. To understand the relationships among bone turnover, material properties, and fracture incidence, we used vibrational spectroscopic imaging to characterize changes in the composition of osteoporotic human bone with antiresorptive pharmaceutical treatment.
This work informs an emerging understanding of the pathophysiology of bisphosphonate-associated atypical fractures debated in the medical literature and reported in the popular press. To examine the contribution of the mineral and collagen constituents to bone mechanical properties across multiple length scales, we examined microstructure-mechanical property relationships in animal models with heterogeneous bone microstructures using nanoindentation, Raman spectroscopic imaging, and second harmonic generation microscopy. Elucidation of microstructure-property relationships in normal and pathologic bone generates insights into the contribution of tissue material properties to skeletal integrity and the processes by which the load-bearing capability of bone is degraded in pathologic tissue. For more info, please visit www.biomed.drexel.edu. |
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Location:
Papadakis Integrated Sciences Building (PISB), Room 120, located at the corner of 33rd and Chestnut Streets. |
Audience:
Undergraduate StudentsGraduate StudentsFacultyStaff |
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