| Start Date: | 6/8/2016 | Start Time: | 9:00 AM |
| End Date: | 6/8/2016 | End Time: | 11:00 AM |
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Event Description
BIOMED Master's Thesis Defense
Title:
Determine the Effect of Non-thermal Plasma Treated Antimicrobial Solution on Resistance of Carbapenem-resistant Acinetobacter Baumannii (CRAB) Isolates
Speaker:
Rubina Narang, MS Candidate, School of Biomedical Engineering, Science and Health Systems
Advisors:
Suresh Joshi, MD, PhD, Professor, Department of Microbiology and Immunology, Drexel University College of Medicine
Andres Kriete, PhD, Associate Teaching Professor, School of Biomedical Engineering, Science and Health Systems
Abstract:
Acinetobacter baumannii is the third most common, Gram-negative, opportunistic pathogen responsible for nosocomial (hospital-acquired) infections in healthcare units world-wide. Carbapenems are considered to be the last resort to treat such infections, but a recent increase in resistance of A. baumannii against the carbapenem group of antimicrobial agents is posing a great threat in control of this pathogen and leading to almost no therapeutic options available for clinicians to treat such infections.
Joshi Laboratory recently isolated multidrug-resistant, carbapenem-resistant A. baumannii (CRAB) bacterial pathogens from the Drexel University College of Medicine’s Hahnemann University Hospital, which exhibits multiple mechanisms of carbapenem resistance. A membrane-associated drug-efflux pump is one of the major mechanisms of carbapenem resistance that can efflux carbapenem and other classes of antibiotics in A. baumannii. The current pump inhibitors used in clinical setup are non-effective due to the increased resistance against them, or confer high toxicity. Joshi Laboratory reported novel antimicrobial, non-thermal plasma-activated antibacterial solutions that are broad-spectrum in nature. These antibacterial solutions are being explored for their exact mechanisms of action on a prototype pathogen, clinical isolate #22, which is CRAB.
The specific aim of the present study is to reconfirm the findings of the antimicrobial effect of a non-thermal plasma-activated, novel antibacterial solution, and to determine the effect of a commonly used efflux-pump inhibitor, carbonyl cyanide m-chlorophenyl hydrazone (CCCP), and a non-thermal plasma-activated antibacterial solution, on locally isolated CRAB # 22, and then correlate with the inhibition of drug-efflux pump. This research work is complementary to past and current research being carried out in Joshi Laboratory at Drexel University. |
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Location:
Papadakis Integrated Sciences Building (PISB), Room 104, located on the northeast corner of 33rd and Chestnut Streets. |
Audience:
Undergraduate StudentsGraduate StudentsFacultyStaff |
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