| Start Date: | 8/4/2016 | Start Time: | 2:00 PM |
| End Date: | 8/4/2016 | End Time: | 4:00 PM |
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Event Description
BIOMED PhD Research Proposal
Title:
Long-term Prevention of Biofilm Formation on Silicone Urinary Catheters Utilizing Thin Film Coatings
Speaker:
Camilla Nix, PhD Candidate, School of Biomedical Engineering, Science and Health Systems
Advisor:
Yinghui Zhong, PhD, Assistant Professor, School of Biomedical Engineering, Science and Health Systems
Abstract:
Long term urinary catheterization is a major cause of 80% of nosocomial infections of the urinary tract, which can lead to device failure. The infection is mainly caused by bacteria, and protein adhesion to the surface, which can develop into a biofilm. Biofilms are hard to treat, making device removal the only effective option. Despite removal of the infected device, patients still have a high risk for reinfection of the newly implanted device. Surface modification of the catheter device to confer anti-bacterial and anti-adhesive properties have been successful in preventing formation, but only for a limited time.
The development of a multicomponent film capable of preventing adhesion, and treating infection may serve to prevent biofilm formation. In this presentation, the rationale and methodology for the characterization of that film is described. The film will consist of a base layer to modify the silicone surface, a drug releasing layer that exhibits anti-bacterial properties, and an anti-adhesive layer for the prevention of adhesion to the device surface.
The aims for this project will involve the in vitro and in vivo characterization of this film, as well as an investigation into the mechanisms that attribute to film behavior. |
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Location:
Bossone Research Center, Room 709, located at 32nd and Market Streets. |
Audience:
Undergraduate StudentsGraduate StudentsFacultyStaff |
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