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Regulated Assembly of the Hierarchical Structure of Tendons and Ligaments
Start Date: 10/26/2016Start Time: 4:00 PM
End Date: 10/26/2016End Time: 5:30 PM

Event Description
BIOMED Seminar

Title:
Regulated Assembly of the Hierarchical Structure of Tendons and Ligaments

Speaker:
David E. Birk, PhD
Distinguished Professor
Department of Molecular Pharmacology and Physiology
Morsani College of Medicine
University of South Florida (USF)

Abstract:
The hierarchical structure of tendons is related to function. Tendon development and the reacquisition of function after injury requires the coordinate regulation of sequential steps in extracellular matrix assembly. These regulatory steps include extracellular macromolecular interactions involving fibril-forming collagens, small leucine-rich proteoglycans and fibril-associated collagens, among others. Disruption of any step(s) results in altered assembly of the structural hierarchy and abnormal function. In addition, mutations associated with congenital diseases also can disrupt these regulatory interactions resulting in abnormal function associated with the pathology.

This presentation will highlight regulatory interactions in the sequence of events leading to establishment of normal tendon structure and function as well as the consequences of disrupting these interactions in musculoskeletal disease.

For more info, please visit drexel.edu/biomed.

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Biosketch:
David E. Birk, PhD, is currently a USF Health Distinguished Professor in the Department of Molecular Pharmacology and Physiology, with a secondary appointment in the Department of Orthopaedics and Sports Medicine at the University of South Florida, Morsani College of Medicine. He received his PhD from Wayne State University. Dr. Birk then did a post-doctoral fellowship at the Shriners Burns Institute/Massachusetts General Hospital/Harvard Medical School and Department of Pathology at Robert Wood Johnson Medical School. He remained in New Jersey as an Assistant and Associate Professor of Pathology before moving to the Department of Anatomy and Cellular Biology at Tufts University, where he was promoted to Professor. In 1998, he moved to Thomas Jefferson University where he was Professor of Pathology, Anatomy and Cell Biology for 10 years.

During his tenure at the University of South Florida, Dr. Birk has held several administrative roles including: Scientific Director of the Lisa Muma Weitz Advanced Microscopy & Cell Imaging Core Facility at USF Health from 2007-2013; the Director of Musculoskeletal Research in the Department of Orthopaedics & Sports Medicine from 2008-2010; and Vice Chair for Cell Biology in the Department of Pathology & Cell Biology from 2008-2012.

Dr. Birk has been a member of study sessions and peer review panels for organizations as NIH, TATRC, Welcome Trust, Shriners Hospitals for Children and several others. He is a Section Editor for Experimental Eye Research and an Associate Editor for Matrix Biology and Connective Tissue Research. He has held various organizing roles in many national and international scientific meetings and routinely lectures nationally and internationally by invitation.

Dr. Birk is internationally recognized for his work on cell and developmental biology, as well as pathobiology of the extracellular matrix. His research has been continuously funded by multiple grants from the National Institutes of Health for over 30 years and is currently PI of 3 NIH awards from NIAMS. He has published over 170 peer-reviewed articles and numerous reviews and book chapters.      
Contact Information:
Name: Ken Barbee
Phone: 215-895-1335
Email: barbee@drexel.edu
David E. Birk
Location:
Papadakis Integrated Sciences Building (PISB), Room 120, located on the northeast corner of 33rd and Chestnut Streets.
Audience:
  • Undergraduate Students
  • Graduate Students
  • Faculty
  • Staff
  • Special Features:
  • Online Access

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