Drexel University - Comprehensive, integrated academics enhanced by co-operative education, technology, and research opportunities. | Drexel University
Drexel University
Search events. View events.

All Categories

Click for help in using calendar displays. Print the contents of the current screen.
Display Format: 
Event Details
Notify me if this event changes.Add this event to my personal calendar.
Go Back
Oral Qual: "Oligomerization of Amyloid Beta -Protein in Crowded Environments"
Start Date: 5/20/2013Start Time: 1:30 PM
End Date: 5/20/2013End Time: 2:30 PM

Event Description

Graduate Student: Matthew Voelker

Abstract: Alzheimer's Disease is strongly associated with small oligomeric assemblies formed by amyloid b-protein (ABeta), in particular with the 42 amino acids-long ABeta1-42. Recently, ABeta1-42 oligomer structure has been characterized computationally by discrete molecular dynamics (DMD) combined with implicit-solvent intermediate-resolution protein model. In vivo, ABeta1-42 coexists with other proteins and biomolecules in a crowded environment. To understand the effects of crowding on ABeta1-42 assembly, we simulated ABeta1-42 oligomer formation in the presence of crowders using the DMD approach described above. Analysis of the resulting conformations yielded an increased number of lower-order oligomers for simulations containing crowders. The monomers, tetramers, pentamers, and hexamers we observed in the presence of crowders had more Beta-strands at the N-terminus and in the central region. These conformations also had an increase in the number of contacts between the C-terminus and central region, implying more compact monomers and oligomers. Monomers with crowders also had a notably larger number of contacts between the N-terminus and C-terminus. The increased content of Beta-strands and more compact monomers and oligomers we observed are in agreement with current theoretical predictions and experimental results regarding the effects of crowding upon protein assembly.

 Advisor: Dr. Brigita Urbanc

Contact Information:
Name: Matthew Voelker
Phone: (215) 895-2732
Email: matthew.j.voelker@drexel.edu
MV
Location:
Disque Hall Room 919
Audience:
  • Current Students
  • Faculty

  • Display Month:

    Advanced Search (New Search)
    Date Range:
    Time Range:
    Category(s):
    Audience: 

    Special Features: 

    Keyword(s):
    Submit
    Select item(s) to Search



    Select item(s) to Search
    Select item(s) to Search
    Select item(s) to Search