Events Calendar for Drexel UniversityClick here to Print
Event Details
Notify me if this event changes.Add this event to my personal calendar.
Go Back
An Integrated, Scalable Platform for rAAV Vector Development with Translational Success
Start Date: 5/8/2023Start Time: 1:30 PM
End Date: 5/8/2023End Time: 3:30 PM
Event Description
BIOMED PhD Research Proposal

Title:
An Integrated, Scalable Platform for rAAV Vector Development with Translational Success

Speaker:
Xueyuan Liu, PhD Candidate
School of Biomedical Engineering, Science and Health Systems
Drexel University

Advisors:
Beverly Davidson, PhD
Professor of Pathology and Laboratory Medicine
Director, Raymond G. Perelman Center for Cellular and Molecular Therapeutics
Perelman School of Medicine
University of Pennsylvania
Chief Scientific Strategy Officer (CSS)
Children's Hospital of Philadelphia (CHOP) Research Institute

Lin Han, PhD
Associate Professor
School of Biomedical Engineering, Science and Health Systems
Drexel University

Details:
This proposal aims to develop an integrated, scalable, high-throughput recombinant adeno-associated virus (rAAV) screening and optimization platform to address the challenges associated with vector development and manufacturing. The platform will focus on the early identification of vector manufacturability, which is crucial for the successful translation of novel vectors into the clinic.

The project is divided into three specific aims: (1) establish a scalable, high throughput rAAV manufacturing platform for productivity screening, (2) identify and integrate critical analytical methods with an orthogonal approach for vector purity screening, and (3) devise enzymatically produced linear closed minimal DNA derived from the TelN/telRL system to enhance vector manufacturability. The proposed platform will bridge the gap between discovery and clinical manufacturing, improving vector manufacturability throughout the entire process, and moving novel therapies closer and faster to patients.
Contact Information:
Name: Natalia Broz
Email: njb33@drexel.edu
Xueyuan Liu
Location:
Remote
Audience:
  • Undergraduate Students
  • Graduate Students
  • Faculty
  • Staff

  • Select item(s) to Search



    Select item(s) to Search
    Select item(s) to Search
    Select item(s) to Search