Drexel University Events Calendar

Lean Six Sigma Black Belt (3/6/2021 - 7/10/2021)

Sat, 6 Mar 2021 14:30:00 GMT

Start Date:	3/6/2021	Start Time:	9:30 AM
End Date:	7/10/2021	End Time:	3:30 PM

The Drexel Lean Six Sigma Black Belt training is a comprehensive and rigorous journey that a dedicated student can undertake to expand and hone their continuous improvement skills. Lean Six Sigma Black Belt is designed for professionals with prior Lean Six Sigma experience and whose roles include training individuals and teams, big picture problem-solving, and project leadership.

Facilitated synchronous (live) online teaching is used to demonstrate and practice tools and skills which the student then immediately applies to a real world opportunity. Sessions are fast paced and timed to synchronize with a typical project life cycle. Throughout the Lean Six Sigma Black Belt program, you receive coaching and mentoring, both as part of the classroom group and individually, to maximize your success. Upon completion of the class, project and a final exam the you become a certified Black Belt, able to address larger and more complex challenges.

LEAN SIX SIGMA BLACK BELT DATES AND TIMES

All courses will be delivered synchronous (in real-time) with live instruction from our Black Belt instructors.

Kickoff (project selection discussion): Tuesday, March 2, 12 - 1 p.m.
Saturday, March 6, 9:30 a.m. – 3:30 p.m.
Saturday, March 27, 9:30 a.m. – 3:30 p.m.
Tuesday, April 6, 6:30 – 9 p.m.
Saturday, April 17, 9:30 a.m. – 3:30 p.m.
Tuesday, April 27, 6:30 – 9 p.m.
Saturday, May 8, 9:30 a.m. – 3:30 p.m.
Tuesday, May 18, 6:30 – 9 p.m.
Tuesday, June 8, 6:30 – 9 p.m.
Project Presentation: Saturday, July 10, 9:30 a.m. – 12 p.m.

This course is available for tuition remission for eligible Drexel employees.

Virtual: Pediatrics Grand Rounds (6/18/2021)

Fri, 18 Jun 2021 12:00:00 GMT

Start Date:	6/18/2021	Start Time:	8:00 AM
End Date:	6/18/2021	End Time:	9:00 AM

Topic
Restrictive Blood Transfusion in Cardiac Surgery

Presented By
Hans Haupt, MD, chief of cardiothoracic surgery, Phoenixville Hospital

Target Audience
Physicians, nurse practitioners, nursing personnel, fellows, residents, medical students and other health care professionals who take care of children

Accreditation Statement
Tower Health is accredited by the Pennsylvania Medical Society to provide continuing medical education for physicians.

Tower Health designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Claiming CME Credits
Attendees MUST sign in with the six-digit activity code provided at the session using eeds within 24 hours of the conference start time and complete the online evaluation within 30 days at

http://towerhealth.eeds.com.

Irreversible Inactivation of HIV-1 and SARS-CoV-2 by Targeting Metastable Virus Spike Proteins (6/18/2021)

Fri, 18 Jun 2021 14:00:00 GMT

Start Date:	6/18/2021	Start Time:	10:00 AM
End Date:	6/18/2021	End Time:	12:00 PM

BIOMED PhD Research Proposal

Title:
Irreversible Inactivation of HIV-1 and SARS-CoV-2 by Targeting Metastable Virus Spike Proteins

Speaker:
Aakansha Nangarlia, PhD Candidate
School of Biomedical Engineering, Science and Health Systems
Drexel University

Advisor:
Irwin Chaiken, PhD
Professor of Biochemistry and Molecular Biology
College of Medicine
Drexel University

Details:
Almost four decades ago, the HIV-1 pandemic swept across human populations, infecting 60 million people and causing over 25 million deaths globally. Today, HIV-1 is one of the leading causes of death in the world. The highly active antiretroviral therapy (HAART) has allowed us to prolong our patients' lives and control the disease's transmission, but it is no cure. In order to find a cure for HIV 1 and eradicate it, drugs need to target both HIV-1 viruses and infected cells. Seeing this as an unmet need, the Chaiken lab has devised HIV-1 envelope-targeting irreversible inactivators (EIs) capable of doing just that. These EIs can target the HIV-1 envelope protein, gp120, and cause self-destruction of the HIV-1 envelope in infected cells and viruses. Their unique modes of action make them one-of-a-kind in the market. The compounds include macrocyclic peptide triazoles (cPTs)/ macrocyclic peptide triazole thiols (cPTTs), small CD4-mimetic dual-action lytic inactivators (DLIs), and lectin dual-action lytic inactivators (Lectin-DLIs). Each of these compounds has a unique mode of action, but all are capable of causing irreversible inactivation. These findings have built the foundation for the development of potent HIV-1 inactivators and allowed us to expand our understanding of the mechanism of HIV-1 envelope transformation during infection. The progress leading to developing various EI class inactivators guided the aims of this project. The project will focus on the investigation of mechanism by which the two classes of EI inactivators, cPTs/cPTTs and DLIs, cause irreversible inactivation of HIV-1 and on identifying and designing the next therapeutic lead EIs for HIV-1 treatment.

At the onset of the COVID-19 pandemic, we saw the structural similarities between HIV-1 and SARS-CoV-2. Like HIV-1, the envelope protein of SARS-CoV-2 is critical in viral infection and production. We decided to test our hypothesis of whether EIs can cause irreversible inactivation of SARS-CoV-2 viruses, like that observed with HIV-1, by either disrupting the intrinsic metastability of the spike or spike aggregation. Thus, providing therapeutic leads for COVID-19 treatment. Therefore, the last part of the project will focus on identifying EIs capable of causing irreversible inactivation of SARS-CoV-2 viruses and identifying their mechanism of action.

Overall, the results from this project will set the foundation for the development and advancement of novel potent entry inhibitors for HIV and COVID-19 treatment. Additionally, the results will help advance our understanding of the structural mechanism that an envelope spike undergoes upon viral entry.

Ten at 10: Free-For-All Fridays (1 Wellness Incentive Point Per Day)* (6/18/2021)

Fri, 18 Jun 2021 14:00:00 GMT

Start Date:	6/18/2021	Start Time:	10:00 AM
End Date:	6/18/2021	End Time:	10:10 AM

Incorporating just 10 minutes of healthy activity into your day can add up to a significant difference in your health, wellbeing and quality of life. With that in mind, Human Resources’ A Healthier U Program is encouraging you to participate in our daily “Ten at 10” wellness program for faculty and professional staff. During this era of social distancing, it’s more important than ever that we find ways to maintain meaningful connections to our colleagues. This program addresses that need and also encourages life-sustaining activities that will promote physical and emotional wellbeing.

Supervisors and department heads are encouraged to set a recurring Outlook invite from 10-10:10 a.m., Monday through Friday, and invite their colleagues to participate. Include a link to this website, then check back Monday through Friday to complete the scheduled activity of the day. For larger departments, you might consider organizing activities into groups of 3-10.

If 10 a.m. is a not an ideal time for you or your department, please feel free to tweak the time to meet your needs. We encourage you to participate sometime before lunch if possible, to help you set the tone for your day.

Fridays are "Free-for-All Fridays." Visit the Ten at 10 Website to connect with resources that can help you take advantage of a simple but powerful body-mind reset. Please visit our website and click on "Free-for-All Fridays" to learn more.

You can also earn points toward the Wellness Incentive Program by participating in Ten at 10. To claim your points, log in to the Health Advocate Wellness Incentive Portal at

healthadvocate.com/drexel and click "Ten at 10" in the To Do List (upper right hand corner of the screen). Every date that you participate and enter will earn you 1 wellness point ($1)!

Through March 2022: Seat at the Table Exhibition (6/18/2021)

Fri, 18 Jun 2021 14:00:00 GMT

Start Date:	6/18/2021	Start Time:	10:00 AM
End Date:	6/18/2021	End Time:	6:00 PM

Women 100, a program of Vision 2020, is hosting "Seat at the Table," an exhibition that commemorates the 19th Amendment — establishing women’s right to vote — and asks 100 years later, “Where are we now?” Visitors will experience the current status of gender equality in the U.S. through 3D infographic furniture.

"Seat at the Table" is closed due to the COVID-19 pandemic, and will reopen September 18, 2021. A virtual tour and the multimedia segment of the exhibition are still available. In addition, an educator's guide is available for download for teachers, youth leaders and parents.

When the Kimmel Center reopens, "Seat at the Table" will be presented in the lobby daily from 10 a.m. to 6 p.m., through September 2021.

Learn more about Seat at the Table

Virtual: Spinal Cord Research Meeting (6/18/2021)

Fri, 18 Jun 2021 16:00:00 GMT

Start Date:	6/18/2021	Start Time:	12:00 PM
End Date:	6/18/2021	End Time:	1:00 PM

Presenter:
Leonardo Garcia, PhD, postdoctoral fellow, Dougherty Lab