Event Description
Speaker: Martin Gruebele, U. Illinois.
Title: “Protein and RNA folding from in vitro to in vivo”
Abstract: The environment in the cell modulates the free
energy of proteins and RNA molecules in subtle ways, yet sufficient to shift
folding or binding populations significantly under the right conditions.
I will begin with progress in “in vitro” experimental and computational
studies, and then I will discuss the effects of crowding and biomolecular
interactions, or “quinary structure” inside the cell. Examples include
client-chaperone binding, protein folding, and protein RNA interactions studied
thermodynamically and on a millisecond time scale inside cells.
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