| Start Date: | 5/4/2012 | Start Time: | 4:00 PM |
| End Date: | 5/4/2012 | End Time: | 5:30 PM |
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Event Description
Dr. Sandhya Kortagere, assistant professor in the Department of Microbiology and Immunology and member of the Institute for Molecular Medicine & Infectious Disease in the Drexel University College of Medicine, will discuss how protein-protein recognition and interactions form the basic unit of molecular networks that control cellular and pathological functions in organisms. Therefore, small molecules that modulate protein-protein interactions (PPI) are of enormous significance as therapeutic candidates. Diseases caused by multi-drug resistant pathogens like Plasmodium falciparum, HIV-1 are spreading at an alarming rate and the current repertoire of drugs is simply inefficient at containing these diseases. Dr. Kortagere and her team have developed a novel platform called the Hybrid Structure Based (HSB) method to design small molecule inhibitors to novel PPIs. HSB method is an iterative in silico, in vitroapproach that utilizes structural information from the PPI interface to screen for small molecule inhibitors. In this talk, she will present the HSB algorithm and its applications to designing small molecule inhibitors to PPI derived from pathogens causing infectious diseases. For more info, please visit: www.biomed.drexel.edu. |
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Location:
The Papadakis Integrated Sciences Building (located at the northeast corner of 33rd and Chestnut Streets). |
Audience:
AlumniCurrent StudentsFacultyProspective StudentsPublicStaff |
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