Drexel University - Comprehensive, integrated academics enhanced by co-operative education, technology, and research opportunities. | Drexel University
Drexel University
Search events. View events.

All Categories

Click for help in using calendar displays. Print the contents of the current screen.
Display Format: 
Event Details
Notify me if this event changes.Add this event to my personal calendar.
Go Back
Chemistry Seminar: Development of Novel Chemical Tools for Accessing Unexplored Chemical Spaces
Start Date: 5/8/2018Start Time: 11:00 AM
End Date: 5/8/2018End Time: 12:00 PM

Event Description
Ming-Yu Ngai, PhD, Stony Brook University


Synthetic methodologies that allow access to new chemical spaces are of paramount importance to modern drug discovery. Fluorine-containing compounds represent a unique chemical space that has caused a fundamental paradigm change in life science research over the past 50 years. There is a significant gap, however, between the needs of the chemical industry and the current methodological efficiency of incorporating fluorinated moieties into organic compounds. To bridge this gap, one of our research programs aims to develop novel reagents and general transformations for the synthesis of fluorinated compounds. In this lecture, I will present our recent efforts to establish mild and operationally simple reactions for the installation of understudied trifluoromethoxy (OCF3) group and polyfluoroalkoxy (ORf) groups into organic molecules. These groups are appealing as they can often enhance molecular efficacy by increasing metabolic stability, promoting binding affinity with targets, and improving cellular membrane permeability of the parent compounds. Nevertheless, due to the lack of general synthetic methods for the introduction of these fluorinated groups, their potential has not been fully exploited in pharmaceutical, agrochemical, and materials applications. Thus, we hope that our research program will allow access to and study of unexplored chemical spaces to aid the discovery and development of new drugs, biocompatible materials, bio-probes, and imaging agents.

Contact Information:
Name: Haifeng (Frank) Ji
Phone: 215.895.2562
Email: hj56@drexel.edu
Disque Hall 109, 32 South 32nd Street, Philadelphia, PA 19104
  • Undergraduate Students
  • Graduate Students
  • Faculty
  • Staff

  • Display Month:

    Advanced Search (New Search)
    Date Range:
    Time Range:

    Special Features: 

    Select item(s) to Search

    Select item(s) to Search
    Select item(s) to Search
    Select item(s) to Search