| Start Date: | 3/5/2025 | Start Time: | 2:30 PM |
| End Date: | 3/5/2025 | End Time: | 4:00 PM |
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Event Description
BIOMED Seminar
Title:
Sleep Loss, Proteostasis, and Learning
Speaker:
Nirmala Nirinjini Naidoo, PhD
Research Professor
Division of Sleep Medicine
Perelman School of Medicine
University of Pennsylvania
Details:
Chronic inadequate sleep is widespread in modern societies. Epidemiological studies indicate that chronic short sleep and/or disrupted sleep are all associated with metabolic dysfunction, cardiovascular risk, cognitive impairments, and increased risk for Alzheimer’s disease. Sleep loss also perturbs proteostasis which is critical for cellular function and memory. The direct link between proteostasis, sleep quality, and cognition in aging and disease remain unclear. Our lab investigates the molecular mechanisms underlying the interactions between sleep, proteostasis and aging with a focus on mitigating the effects of sleep loss and impaired proteostasis on learning and pathology.
Biosketch:
Nirmala Nirinjini Naidoo, PhD, is a Research Professor in the Division of Sleep Medicine at the Perelman School of Medicine, University of Pennsylvania. Her research interest lies in understanding the changes in protein homeostasis (proteostasis) in brain in relationship to sleep/wake control and effects of sleep deprivation. Her work has shown that sleep loss perturbs proteostasis and that during aging chronic sleep disturbances impair proteostasis contributing to neuronal injury. Current research in the lab focuses on the mitigating the effects of sleep disruption and impaired proteostasis to neurodegeneration.
Dr. Naidoo has served on numerous NIH study sections on aging and neurodegeneration, is the chair of the NIH external advisory board for the BENFRA Botanical Dietary Supplements Research Center at Oregon Health and Science University and Oregon State University. She is a member of the Neuroscience Graduate Group, the Institute of Aging and the Chronobiology and Sleep Institute (CSI) at Penn. |
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Location:
Papadakis Integrated Sciences Building (PISB), Room 120, located on the northeast corner of 33rd and Chestnut Streets. |
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